Author: Molnupiravir-Stop

Published: 2023-10-25 Keywords: SARS‐CoV‐2, Hydroxychloroquine, Favipiravir, Molnupiravir, Dexamethasone, Kidney damage Abstract Aim: In December 2019, the coronavirus disease was caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Some drugs were repurposed for this disease treatment. Hydroxychloroquine (HCQ), favipiravir (FAV), molnupiravir (MOL), and dexamethasone (DEX) were widely used for the treatment of...

Signature of molnupiravir might be in SARS-CoV-2 genomic sequence. Plus, the everyday chemicals that make us fatter and codebreakers decrypt the long-lost letters of Mary, Queen of Scots. COVID drug might drive viral mutations Molnupiravir, a drug widely used to treat COVID-19, might be spurring the evolution of new SARS-CoV-2...

Hatasu Kobayashi 1, Yurie Mori 2,3, Sharif Ahmed 4, Yuichiro Hirao 5,6, Shinya Kato 7, Shosuke Kawanishi 8, Mariko Murata 9, Shinji Oikawa 10,✉,2 Author information Article notes Copyright and License information PMCID: PMC10132762  PMID: 36461940 Abstract Molnupiravir is an antiviral agent recently used for treating coronavirus disease 2019 (COVID-19). Here, we demonstrate that N4-hydroxycytidine (NHC), a molnupiravir metabolite, treated with cytidine deaminase (CDA) induced Cu(II)-mediated oxidative DNA...

Ikbel Hadj Hassine 1, Manel Ben M'hadheb 1, Luis Menéndez-Arias 2 Affiliations Expand PMID: 35458571 PMCID: PMC9024455 DOI: 10.3390/v14040841 Abstract In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of mutagens, driving viral populations to extinction. Extinction catastrophe can...

Michael D Waters 1, Stafford Warren 2, Claude Hughes 3, Philip Lewis 4, Fengyu Zhang 5 Affiliations Expand PMID: 35023215 DOI: 10.1002/em.22471 Abstract This review considers antiviral nucleoside analog drugs, including ribavirin, favipiravir, and molnupiravir, which induce genome error catastrophe in SARS-CoV or SARS-CoV-2 via lethal mutagenesis as a mode of action. In vitro data indicate that molnupiravir may be 100 times...

Some laboratory studies suggest that molnupiravir can insert errors in DNA, which could in theory harm a developing fetus, sperm cells or children. While molnupiravir has been shown to reduce the risk of hospitalization and death from Covid-19, scientists have raised concerns about the drug’s potential to cause mutations in...