Evaluation of the cardiopulmonary effects of repurposed COVID-19 therapeutics in healthy rats

View news article Abstract Hydroxychloroquine (HCLQ), favipiravir (FAVI), molnupiravir (MOL) and dexamethasone (DEX) are recently used drugs, some of which are currently used in the treatment of Coronavirus Disease (COVID-19). We aimed to investigate the cardiovascular and pulmonary effects of MOL, HCLQ, FAVI and DEX—drugs repurposed or used in COVID-19...

The chemical structures of Molnupiravir, NHC and EIDD-1931-triphopsphate.

View full-text article in PMCFront Immunol . 2022 Apr 4;13:855496. doi: 10.3389/fimmu.2022.855496 Copyright and License information The chemical structures of Molnupiravir, NHC and EIDD-1931-triphopsphate.(A) Molnupiravir, Beta-D-N4-hydroxycytidine-5’-isopropyl ester (MK-4482/EIDD-2801) is a bioactive prodrug of NHC (EIDD-1931). (B) Beta-D-N4-hydroxycytidine(NHC,EIDD-1931) is an orally bioavailable ribonucleoside analogue, which has broad-spectrum activity against a variety of RNA viruses. (C) EIDD-triphosphate can...

Buyer beware: molnupiravir may damage DNA

Buyer beware: molnupiravir may damage DNA J. V. van Schalkwyk Published in British medical journal 4 November 2021 Medicine TLDR There is a certain irony that vaccine shy people who have believed the untruth that vaccines against SARS-CoV-2 alter DNA seem poised to reach for a perceived “alternative” that may actually alter their...