β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells

Shuntai Zhou 1, Collin S Hill 1, Sanjay Sarkar 2, Longping V Tse 3, Blaide M D Woodburn 1 4, Raymond F Schinazi 5, Timothy P Sheahan 3, Ralph S Baric 3 6, Mark T Heise 2 6, Ronald Swanstrom 1 7 Affiliations Expand PMID: 33961695 PMCID: PMC8136050 DOI: 10.1093/infdis/jiab247 Abstract Mutagenic ribonucleosides can act as broad-based antiviral agents. They are metabolized to the active ribonucleoside triphosphate form and concentrate in genomes of RNA viruses during viral...