Signature of molnupiravir might be in SARS-CoV-2 genomic sequence. Plus, the everyday chemicals that make us fatter and codebreakers decrypt the long-lost letters of Mary, Queen of Scots. COVID drug might drive viral mutations Molnupiravir, a drug widely used to treat COVID-19, might be spurring the evolution of new SARS-CoV-2...
A worker handles a bottle of Merck & Co. and Ridgeback Biotherapeutics LPs Molnupiravir antiviral medication in a warehouse in Shoham, Israel, on Jan. 18, 2022. A fourth dose of the Pfizer-BioNTech vaccine was insufficient to prevent infection with the omicron variant of Covid-19, according to preliminary data from a trial...
Hatasu Kobayashi 1, Yurie Mori 2,3, Sharif Ahmed 4, Yuichiro Hirao 5,6, Shinya Kato 7, Shosuke Kawanishi 8, Mariko Murata 9, Shinji Oikawa 10,✉,2 Author information Article notes Copyright and License information PMCID: PMC10132762 PMID: 36461940 Abstract Molnupiravir is an antiviral agent recently used for treating coronavirus disease 2019 (COVID-19). Here, we demonstrate that N4-hydroxycytidine (NHC), a molnupiravir metabolite, treated with cytidine deaminase (CDA) induced Cu(II)-mediated oxidative DNA...
Ikbel Hadj Hassine 1, Manel Ben M'hadheb 1, Luis Menéndez-Arias 2 Affiliations Expand PMID: 35458571 PMCID: PMC9024455 DOI: 10.3390/v14040841 Abstract In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of mutagens, driving viral populations to extinction. Extinction catastrophe can...
Michael D Waters 1, Stafford Warren 2, Claude Hughes 3, Philip Lewis 4, Fengyu Zhang 5 Affiliations Expand PMID: 35023215 DOI: 10.1002/em.22471 Abstract This review considers antiviral nucleoside analog drugs, including ribavirin, favipiravir, and molnupiravir, which induce genome error catastrophe in SARS-CoV or SARS-CoV-2 via lethal mutagenesis as a mode of action. In vitro data indicate that molnupiravir may be 100 times...
Some laboratory studies suggest that molnupiravir can insert errors in DNA, which could in theory harm a developing fetus, sperm cells or children. While molnupiravir has been shown to reduce the risk of hospitalization and death from Covid-19, scientists have raised concerns about the drug’s potential to cause mutations in...
Shuntai Zhou 1, Collin S Hill 1, Sanjay Sarkar 2, Longping V Tse 3, Blaide M D Woodburn 1 4, Raymond F Schinazi 5, Timothy P Sheahan 3, Ralph S Baric 3 6, Mark T Heise 2 6, Ronald Swanstrom 1 7 Affiliations Expand PMID: 33961695 PMCID: PMC8136050 DOI: 10.1093/infdis/jiab247 Abstract Mutagenic ribonucleosides can act as broad-based antiviral agents. They are metabolized to the active ribonucleoside triphosphate form and concentrate in genomes of RNA viruses during viral...
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